The Wine pets version2013 publishes are --like firefox and libreoffice-- not restricted to be used in any one Puppy. Of course, 64-bit versions of Wine can only run under 64-bit Operating Systems. And 32-bit versions of Wine, to be functional, require a 32-bit operating system or the presence of 32-bit compatibility libraries on a 64-bit operating system. Moreover, some versions of Puppy --published before Tahrpup(64) or racy 5.5-- did not contain the files needed to use Wine compiled under Tahrpup(64) or racy 5.5-- and thoughtfully Version2013 compiled versions of Wine that could be used under them.
Since you are running Buster64, you would want the Wine version compiled under Tahrpup64.
Version2013's wine thread can be found here,
http://www.murga-linux.com/puppy/viewto ... 128#725128. It is a little confusing. The first post provides a link to all the versions of wine available. Just select a Wine version number, in blue text, and click on it. That will take you to the post discussing that particular build and providing a link to its download page.
You've asked about Wine 64 5.0. I assume that you know that Wine 64, although --IIRC-- it contains a 32-bit wineserver, will not otherwise run 32-bit Window Programs. For such programs, you would also need a Wine 32 bit version,
Someone can correct me if I'm mistaken [and, perhaps explain how to run 32-bit programs under the 64-bit version].
Version2013 has provided links to both Wine 64 bit Stable and Development versions. Assuming you want the Stable Version, clicking
5.0 under the heading Stable, toward the bottom of the thread, will take you to this post,
http://murga-linux.com/puppy/viewtopic. ... 67#1048967. Clicking
wine-5.0 mirrors will take you to this post,
https://version2013.yolasite.com/page1.php#wine-5.0. You'll note two versions, wine-5.0_v3.1.pet and wine-5.0_v3.2.pet. The "1" indicates it's been stripped (of probably unnecessary files) as opposed to "2" which has not. "2" is recommended if you may need to seek assistance from WineHq. When I remember, I choose "1": I doubt WineHq will be of any assistance when your OS is a frugal install.
Last thing to remember, Version2013's pets do not, themselves, provide menu entries. If you want menu entries, you'll also want to install one of the pets Version32 discusses near the bottom of the first post under the Heading "menu entries".
Edit-afterthought: After downloading the wine-pet, open a terminal and type "wine winecfg".
BUT BE ON-LINE FIRST. When that command is executed, Wine will offer to download and install both mono and gecko. gecko enables running Windows web-browsers and is never needed nor recommended. But some Windows programs require mono. You can probably live without it. However, I've never been able to successfully install it when the opportunity to do so at the very beginning is missed.